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VIRUSES
Viruses are obligate, intracellular
parasites that must enter another cell in order
to multiply. Viruses are made up of genetic material
surrounded by a protein shell called a capsid.
The capsid protects the genetic material from
degradation by exonucleases and, for some viruses,
plays a role in the attachment of the virus to
target cells. The proteins that form the capsid
are known as protomers and these join together
in a process known as self-assembly. As the protomers
assemble, the characteristic helical or icosahedral
shape of the capsid takes form. Some viruses have
capsids that are surrounded by portions of the
host cell's membrane; these types of viruses are
referred to as "enveloped."
Some viruses have spike proteins
that extend from the capsid, whereas enveloped
viruses have spike proteins that project from
the envelope. These spike proteins are important
in recognizing and binding to specific structures
on the surface of target cells. This is an important
feature because the spike proteins define the
types of cells that the virus is able to attach
to and enter. Antibodies, protective molecules
produced by the immune system, are able to bind
to the spike proteins and prevent viral attachment
to target cells.
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