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THE LACTOSE
OPERON
The term operon refers to a gene complex
consisting of a group of structural genes with
related fuctions, plus the closely linked DNA
sequences responsible for controlling them. For
example, the structural genes of the lactose operonlac
Z, lac Y, and lac Acode
for -galactosidase,
galactose permease, and galactoside transacetylase,
respectively.
Because all three enzymes are
translated from the same mRNA molecule, a single
molecular "switch" must coordinate their
synthesis. The switch that controls mRNA synthesis
is called the operator; it is a sequence
of bases that is upstream from the first structural
gene in the operon and that overlaps part of the
promoter region.
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